IL-21 and CD40L signals from autologous T cells can induce antigen-independent proliferation of CLL cells-Reference-Cited by-同舟云学术

IL-21 and CD40L signals from autologous T cells can induce antigen-independent proliferation of CLL cells

Published:2013-10-24 Issue:17 Volume:122 Page:3010-3019
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Pascutti Maria Fernanda¹²,Jak Margot²,Tromp Jacqueline M.²,Derks Ingrid A. M.¹,Remmerswaal Ester B. M.¹,Thijssen Rachel¹²,van Attekum Martijn H. A.¹²,van Bochove Gregor G.¹²,Luijks Dieuwertje M.²,Pals Steven T.³⁴,van Lier René A. W.¹,Kater Arnon P.²⁴,van Oers Marinus H. J.²⁴,Eldering Eric¹⁴

Affiliation:

1. Department of Experimental Immunology,

2. Department of Hematology, and

3. Department of Pathology, Academisch Medisch Centrum, Universiteit van Amsterdam, Amsterdam, The Netherlands; and

4. Lymphoma and Myeloma Center, Amsterdam, The Netherlands

Abstract

Key Points Autologous activated T cells can drive antigen-independent proliferation of CLL cells through CD40 and IL-21 signaling. An IL-21 gene induction signature, IL-21 mRNA, and protein can be found in CLL lymph node samples.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/122/17/3010/1370330/3010.pdf

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