Persistent neonatal thrombocytopenia can be caused by IgA antiplatelet antibodies in breast milk of immune thrombocytopenic mothers-Reference-Cited by-同舟云学术

Persistent neonatal thrombocytopenia can be caused by IgA antiplatelet antibodies in breast milk of immune thrombocytopenic mothers

Published:2015-07-30 Issue:5 Volume:126 Page:661-664
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Hauschner Hagit¹,Rosenberg Nurit¹,Seligsohn Uri¹,Mendelsohn Rafael²³,Simmonds Aryeh³⁴,Shiff Yakov³⁴,Schachter Yaakov²³,Aviner Shraga⁵,Sharon Nechama³⁶

Affiliation:

1. Amalia Biron Research Institute of Thrombosis and Hemostasis, Chaim Sheba Medical Center, Tel Hashomer and Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel;

2. Pediatric Department, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel;

3. Ruth and Bruce Rappoport Faculty of Medicine, Technion, Haifa, Israel;

4. Neonatology Unit, Laniado Hospital, Netanya, Israel;

5. Department of Pediatrics, Barzilai University Medical Center, Ashkelon, and Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer Sheva, Israel; and

6. Pediatric Hemato-oncology Department, Laniado Hospital, Netanya, Israel

Abstract

Key Points Persistent thrombocytopenia was observed in breastfed neonates of ITP women. Breast milk of ITP women may contain immunoglobulin A antiplatelet antibodies, which target αIIbβ3 integrin.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/126/5/661/1391634/661.pdf

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4. Standardization of terminology, definitions and outcome criteria in immune thrombocytopenic purpura of adults and children: report from an international working group.;Rodeghiero;Blood,2009

5. Intestinal absorption of immunoglobulins by newborn infants.;Iyengar;Arch Dis Child,1972

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