Pml nuclear body disruption cooperates in APL pathogenesis and impairs DNA damage repair pathways in mice-Reference-Cited by-同舟云学术

Pml nuclear body disruption cooperates in APL pathogenesis and impairs DNA damage repair pathways in mice

Published:2018-02-08 Issue:6 Volume:131 Page:636-648
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Voisset Edwige¹^ORCID,Moravcsik Eva¹,Stratford Eva W.²,Jaye Amie¹,Palgrave Christopher J.³,Hills Robert K.⁴,Salomoni Paolo⁵,Kogan Scott C.⁶⁷,Solomon Ellen¹,Grimwade David¹

Affiliation:

1. Department of Medical and Molecular Genetics, Faculty of Life Sciences and Medicine, King’s College London, London, United Kingdom;

2. Department of Tumor Biology, The Norwegian Radium Hospital/Oslo University Hospital, Oslo, Norway;

3. School of Veterinary Medicine, University of Surrey, Guildford, United Kingdom;

4. Centre for Trials Research, College of Biomedical & Life Sciences, Cardiff University, Cardiff, United Kingdom;

5. UCL Cancer Institute, London, United Kingdom; and

6. Helen Diller Family Comprehensive Cancer Center and

7. Department of Laboratory Medicine, University of California, San Francisco, CA

Abstract

Key Points A novel mouse model elucidates the impact of Pml NB disruption on APL pathogenesis and response to targeted therapy. The mode of action of this disruption appears to be via the perturbation of the NHEJ and HR pathways.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/131/6/636/1466576/blood794784.pdf

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