Taking ALPS down a Notch

Abstract

Notch activation is an early and critical event during T-cell leukemogenesis, hence Notch signal inhibition is a desirable and feasible intervention to abrogate the process of lymphocyte accumulation and antibody production secondary to apoptosis defects as shown in 2 murine models here. However, prudent and diligent assessment of the risks and benefits of any such therapies should be imperative, especially in many nonmalignant lymphoproliferative and autoimmune disorders, including autoimmune lymphoproliferative syndrome (ALPS).