Regulation of Immune Responses by Histone Deacetylase Inhibitors

Author:

Licciardi Paul V.12ORCID,Karagiannis Tom C.34ORCID

Affiliation:

1. Allergy and Immune Disorders Group, Murdoch Childrens Research Institute, Melbourne, VIC 3052, Australia

2. Department of Paediatrics, University of Melbourne, Melbourne, VIC 3052, Australia

3. Epigenomic Medicine Laboratory, Baker IDI Heart & Diabetes Institute, Melbourne, VIC 3004, Australia

4. Department of Pathology, University of Melbourne, Parkville, VIC 3052, Australia

Abstract

Both genetic and epigenetic factors are important regulators of the immune system. There is an increasing body of evidence attesting to epigenetic modifications that influence the development of distinct innate and adaptive immune response cells. Chromatin remodelling via acetylation, methylation, phosphorylation, and ubiquitination of histone proteins as well as DNA, methylation is epigenetic mechanisms by which immune gene expression can be controlled. In this paper, we will discuss the role of epigenetics in the regulation of host immunity, with particular emphasis on histone deacetylase inhibitors. In particular, the role of HDAC inhibitors as a new class of immunomodulatory therapeutics will also be reviewed.

Publisher

Hindawi Limited

Subject

General Earth and Planetary Sciences,General Environmental Science

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