MLL fusion protein–driven AML is selectively inhibited by targeted disruption of the MLL-PAFc interaction-Reference-Cited by-同舟云学术

MLL fusion protein–driven AML is selectively inhibited by targeted disruption of the MLL-PAFc interaction

Published:2013-09-12 Issue:11 Volume:122 Page:1914-1922
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Muntean Andrew G.¹,Chen Wei¹,Jones Morgan²³,Granowicz Eric M.¹,Maillard Ivan²⁴⁵,Hess Jay L.¹

Affiliation:

1. Department of Pathology, Department of Medicine;

2. Center for Stem Cell Biology, Life Sciences Institute;

3. Cellular and Molecular Biology Program, Division of Hematology-Oncology;

4. Department of Medicine; and

5. Department of Cell and Developmental Biology, University of Michigan Medical School, Ann Arbor, MI

Abstract

Key Points The PAFc subunit, Cdc73, is required for the proliferation and proper epigenetic regulation of proleukemic oncogenes in AML cells. Disrupting the MLL-PAFc interaction selectively inhibits the growth of MLL-associated leukemic cells without altering normal hematopoietic stem cell function.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/122/11/1914/1330906/1914.pdf

Reference30 articles.

1. The pathogenesis of mixed-lineage leukemia.;Muntean;Annu Rev Pathol,2012

2. Novel prognostic subgroups in childhood 11q23/MLL-rearranged acute myeloid leukemia: results of an international retrospective study.;Balgobind;Blood,2009

3. Molecular rearrangements on chromosome 11q23 predominate in infant acute lymphoblastic leukemia and are associated with specific biologic variables and poor outcome.;Chen;Blood,1993

4. Licensed to elongate: a molecular mechanism for MLL-based leukaemogenesis.;Mohan;Nat Rev Cancer,2010

5. Binding of the MLL PHD3 finger to histone H3K4me3 is required for MLL-dependent gene transcription.;Chang;J Mol Biol,2010

Cited by 16 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. The YEATS domain epigenetic reader proteins ENL and AF9 and their therapeutic value in leukemia;Experimental Hematology;2023-08

2. The ENL YEATS epigenetic reader domain critically links MLL-ENL to leukemic stem cell frequency in t(11;19) Leukemia;Leukemia;2022-11-26

3. Mutational landscape and clinical outcome of pediatric acute myeloid leukemia with 11q23/ KMT2A rearrangements;Cancer Medicine;2022-07-14

4. The role of E2A in ATPR‐induced cell differentiation and cycle arrest in acute myeloid leukaemia cells;Journal of Cellular and Molecular Medicine;2022-01-09

5. Discovery of first-in-class inhibitors of ASH1L histone methyltransferase with anti-leukemic activity;Nature Communications;2021-05-14