The glutaminase activity of l-asparaginase is not required for anticancer activity against ASNS-negative cells-Reference-Cited by-同舟云学术

The glutaminase activity of l-asparaginase is not required for anticancer activity against ASNS-negative cells

Published:2014-06-05 Issue:23 Volume:123 Page:3596-3606
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Chan Wai Kin¹,Lorenzi Philip L.¹^ORCID,Anishkin Andriy²,Purwaha Preeti¹,Rogers David M.³,Sukharev Sergei⁴,Rempe Susan B.³,Weinstein John N.¹

Affiliation:

1. Department of Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer Center, Houston, TX;

2. Center for Computational Proteomics, Huck Institute of Life Sciences, Pennsylvania State University, State College, PA;

3. Center for Biological and Materials Sciences, Sandia National Laboratories, Albuquerque, NM; and

4. Department of Biology, University of Maryland, College Park, MD

Abstract

Key Points We used molecular dynamics, saturation mutagenesis, and enzymologic screening to develop a glutaminase-free mutant (Q59L) l-ASP. We then used Q59L to show that glutaminase activity is not required for l-ASP activity against ASNS-negative cancer cells.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/123/23/3596/1377800/3596.pdf

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