Production Process Optimization of Recombinant <i>Erwinia carotovora</i> <scp>l</scp>-Asparaginase II in <i>Escherichia coli</i> Fed-Batch Cultures and Analysis of Antileukemic Potential-Reference-Cited by-同舟云学术

Production Process Optimization of Recombinant Erwinia carotovora l-Asparaginase II in Escherichia coli Fed-Batch Cultures and Analysis of Antileukemic Potential

Published:2024-08-03 Issue:32 Volume:9 Page:34951-34963
ISSN:2470-1343
Container-title:ACS Omega
language:en
Short-container-title:ACS Omega

Author:

de Andrade Bruna Coelho¹²,Renard Gaby³,Gennari Adriano⁴,Artico Leonardo Luís⁵⁶,Júnior José Ricardo Teixeira⁵⁶,Kuhn Daniel⁴,Salles Priscila Pini Zenatti⁵⁶,Volken de Souza Claucia Fernada⁴^ORCID,Roth Gustavo⁷,Chies Jocelei Maria³,Yunes José Andrés⁵⁸,Basso Luiz Augusto¹²⁹^ORCID

Affiliation:

1. National Institute of Science and Technology in Tuberculosis, Research Center for Molecular and Functional Biology, Pontifical Catholic University of Rio Grande do Sul, Porto Alegre, Rio Grande do Sul 90619-900, Brazil

2. Graduate Program in Medicine and Health Sciences, Pontifical Catholic University of Rio Grande do Sul, Porto Alegre, Rio Grande do Sul 90619-900, Brazil

3. Quatro G Pesquisa & Desenvolvimento Ltd., Porto Alegre, Rio Grande do Sul 90619-900, Brazil

4. Food Biotechnology Laboratory, Biotechnology Graduate Program, University of Vale do Taquari (UNIVATES), Lajeado, Rio Grande do Sul 95914-014, Brazil

5. Centro Infantil Boldrini, Campinas, São Paulo 13083-210, Brazil

6. Graduate Program in Genetics and Molecular Biology, Biology Institute, State University of Campinas, Campinas, São Paulo 13083-970, Brazil

7. Pontifical Catholic University of Rio Grande do Sul, Porto Alegre, Rio Grande do Sul 90619-900, Brazil

8. Department of Medical Genetics, Faculty of Medical Sciences, State University of Campinas, Campinas, São Paulo 13083-970, Brazil

9. Graduate Program in Cellular and Molecular Biology, Pontifical Catholic University of Rio Grande do Sul, Porto Alegre, Rio Grande do Sul 90619-900, Brazil

Funder

Pontif?cia Universidade Cat?lica do Rio Grande do Sul

Conselho Nacional de Desenvolvimento Cient?fico e Tecnol?gico

Funda??o de Amparo ? Pesquisa do Estado do Rio Grande do Sul

Funda??o de Amparo ? Pesquisa do Estado de S?o Paulo

Coordena??o de Aperfei?oamento de Pessoal de N?vel Superior

Publisher

American Chemical Society (ACS)

Link

https://pubs.acs.org/doi/pdf/10.1021/acsomega.4c04711

Reference63 articles.

1. Bacterial l ‐asparaginases for cancer therapy: Current knowledge and future perspectives

2. Expression, purification, and characterization of asparaginase II from Saccharomyces cerevisiae in Escherichia coli

3. Glutaminase activity determines cytotoxicity of l-asparaginases on most leukemia cell lines

4. A Comprehensive Review on l-Asparaginase and Its Applications

5. Possible mechanism of metabolic and drug resistance with L-asparaginase therapy in childhood leukaemia