GPR84 sustains aberrant β-catenin signaling in leukemic stem cells for maintenance of MLL leukemogenesis

Author:

Dietrich Philipp A.1,Yang Chen1,Leung Halina H. L.1,Lynch Jennifer R.1,Gonzales Estrella1,Liu Bing23,Haber Michelle3,Norris Murray D.3,Wang Jianlong4,Wang Jenny Yingzi15ORCID

Affiliation:

1. Cancer and Stem Cell Biology Group, Children’s Cancer Institute Australia, Lowy Cancer Research Centre, University of New South Wales, Sydney, NSW, Australia;

2. Kids Cancer Alliance, Translational Cancer Research Centre for Kids, Cancer Institute New South Wales, Sydney, NSW, Australia;

3. Children’s Cancer Institute Australia, Lowy Cancer Research Centre, University of New South Wales, Sydney, NSW, Australia;

4. Department of Developmental and Regenerative Biology, Black Family Stem Cell Institute, Icahn School of Medicine at Mount Sinai, New York, NY; and

5. School of Women’s and Children’s Health, Faculty of Medicine, University of New South Wales, Sydney, NSW, Australia

Abstract

Key Points GPR84 simultaneously augments β-catenin signaling and an oncogenic transcription program essential for establishment of MLL. Our study demonstrates a strong dependence of hematopoietic stem cell–derived MLL leukemic cells on GPR84 for disease maintenance in vivo.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

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