The Wnt/β-Catenin Pathway Is Required for the Development of Leukemia Stem Cells in AML-Reference-Cited by-同舟云学术

The Wnt/β-Catenin Pathway Is Required for the Development of Leukemia Stem Cells in AML

Published:2010-03-26 Issue:5973 Volume:327 Page:1650-1653
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Wang Yingzi¹,Krivtsov Andrei V.¹,Sinha Amit U.¹²,North Trista E.³⁴,Goessling Wolfram⁴⁵⁶,Feng Zhaohui¹²,Zon Leonard I.¹⁴⁷,Armstrong Scott A.¹²⁴

Affiliation:

1. Division of Hematology/Oncology, Children’s Hospital, Harvard Medical School, Boston, MA 02115, USA.

2. Department of Pediatric Oncology, Harvard Medical School, Boston, MA 02115, USA.

3. Department of Pathology, Beth Israel Deaconess Hospital, Harvard Medical School, Boston, MA 02115, USA.

4. Harvard Stem Cell Institute, Harvard Medical School, Boston, MA 02115, USA.

5. Medical Oncology, Dana Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA.

6. Division of Genetics, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA 02115, USA.

7. Howard Hughes Medical Institute, Chevy Chase, MD 20815, USA.

Abstract

A Pathway to Leukemia Leukemia is initiated and maintained by a small number of self-renewing cells called leukemia stem cells (LSCs), which share properties with hematopoietic stem cells (HSCs), the self-renewing cells that produce healthy blood cells. Wang et al. (p. 1650 ) studied mouse models of acute myelogenous leukemia (AML), a disease that is often refractory to existing therapies. Activation of the Wnt/β-catenin signaling pathway was required for efficient oncogene-mediated conversion of HSCs into LSCs. This pathway is among the most well studied signaling pathways in cell biology, setting the stage for testing of β-catenin signaling antagonists in preclinical models of AML.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference25 articles.

1. Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell

2. Stem cell concepts renew cancer research

3. Cancer Stem Cell–Directed Therapies: Recent Data From the Laboratory and Clinic

4. Jamieson C. H., et al.., J. Med. 351, 657 (2004).

5. Dysregulated gene expression networks in human acute myelogenous leukemia stem cells

Cited by 655 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Concomitant targeting of FLT3 and SPHK1 exerts synergistic cytotoxicity in FLT3-ITD+ acute myeloid leukemia by inhibiting β-catenin activity via the PP2A-GSK3β axis;Cell Communication and Signaling;2024-08-07

2. Loss of the stress sensor GADD45A promotes stem cell activity and ferroptosis resistance in LGR4/HOXA9-dependent AML;Blood;2024-07-04

3. RHOF activation of AKT/β-catenin signaling pathway drives acute myeloid leukemia progression and chemotherapy resistance;iScience;2024-07

4. Wnt/β-catenin signaling pathway in carcinogenesis and cancer therapy;Journal of Hematology & Oncology;2024-06-18

5. EV-mediated intercellular communication in acute myeloid leukemia: Transport of genetic materials in the bone marrow microenvironment;Experimental Hematology;2024-05