Inhibition of HPA-1a alloantibody-mediated platelet destruction by a deglycosylated anti–HPA-1a monoclonal antibody in mice: toward targeted treatment of fetal-alloimmune thrombocytopenia-Reference-Cited by-同舟云学术

Inhibition of HPA-1a alloantibody-mediated platelet destruction by a deglycosylated anti–HPA-1a monoclonal antibody in mice: toward targeted treatment of fetal-alloimmune thrombocytopenia

Published:2013-07-18 Issue:3 Volume:122 Page:321-327
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Bakchoul Tamam¹²,Greinacher Andreas¹,Sachs Ulrich J.²,Krautwurst Annika²,Renz Harald³,Harb Habi³,Bein Gregor²,Newman Peter J.⁴,Santoso Sentot²

Affiliation:

1. Institute for Immunology and Transfusion Medicine, Ernst Moritz Arndt University, Greifswald, Germany;

2. Institute for Clinical Immunology and Transfusion Medicine, Justus Liebig University, Giessen, Germany;

3. Institute for Laboratory Medicine and Pathobiochemistry, Molecular Diagnostics, Philipps Marburg University, Germany; and

4. Blood Research Institute, BloodCenter of Wisconsin, Milwaukee, WI

Abstract

Key Points The study describes a potential novel treatment of fetal alloimmune thrombocytopenia by dissecting the effector activities of an epitope-specific IgG antibody. Neither the in vivo transplacental transport nor the inhibiting properties of the blocking antibody are impaired by the N-glycan modification.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/122/3/321/1372167/321.pdf

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