Evidence for the Role of a Second Fc-Binding Receptor in Placental IgG Transfer in Nonhuman Primates-Reference-Cited by-同舟云学术

Evidence for the Role of a Second Fc-Binding Receptor in Placental IgG Transfer in Nonhuman Primates

Published:2023-04-25 Issue:2 Volume:14 Page:
ISSN:2150-7511
Container-title:mBio
language:en
Short-container-title:mBio

Author:

Rosenberg Yvonne J.¹^ORCID,Ordonez Tracy²,Khanwalkar Urjeet S.³,Barnette Philip²,Pandey Shilpi²,Backes Iara M.⁴,Otero Claire E.⁵,Goldberg Benjamin S.³,Crowley Andrew R.⁴,Leib David A.⁴,Shapiro Mariya B.²,Jiang Xiaoming¹,Urban Lori A.¹,Lees Jonathan¹,Hessell Ann J.²,Permar Sallie⁵,Haigwood Nancy L.²,Ackerman Margaret E.³⁴^ORCID

Affiliation:

1. PlantVax, Inc., Rockville, Maryland, USA

2. Oregon National Primate Research Center, Oregon Health & Science University, Beaverton, Oregon, USA

3. Thayer School of Engineering, Dartmouth College, Hanover, New Hampshire, USA

4. Geisel School of Medicine, Dartmouth College, Hanover, New Hampshire, USA

5. Department of Pediatrics, Weill Cornell Medicine, New York, New York, USA

Abstract

This study compared the ability of several human HIV envelope-directed monoclonal antibodies produced in plants with the same antibodies produced in mammalian cells for their ability to cross monkey and mouse placentas. We found that the two types of antibodies have comparable transfer efficiencies in mice, but they are differentially transferred across macaque placentas, consistent with a two-receptor IgG transport model in primates.

Funder

HHS | NIH | NIH Office of the Director

HHS | NIH | National Institute of Allergy and Infectious Diseases

Publisher

American Society for Microbiology

Subject

Virology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/mbio.00341-23

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