CBFA2T3-GLIS2 fusion transcript is a novel common feature in pediatric, cytogenetically normal AML, not restricted to FAB M7 subtype-Reference-Cited by-同舟云学术

CBFA2T3-GLIS2 fusion transcript is a novel common feature in pediatric, cytogenetically normal AML, not restricted to FAB M7 subtype

Published:2013-04-25 Issue:17 Volume:121 Page:3469-3472
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Masetti Riccardo¹,Pigazzi Martina²,Togni Marco¹,Astolfi Annalisa³,Indio Valentina³,Manara Elena²,Casadio Rita⁴,Pession Andrea¹,Basso Giuseppe²,Locatelli Franco⁵

Affiliation:

1. Department of Pediatrics, Lalla Seràgnoli, Hematology-Oncology Unit, University of Bologna, Italy;

2. Department of Woman and Child Health, Laboratory of Hematology-Oncology, University of Padova, Padova, Italy;

3. Giorgio Prodi Cancer Research Center, University of Bologna,

4. Biocomputing Group, Department of Biological, Geological and Environmental Sciences, University of Bologna, Bologna, Italy; and

5. Department of Pediatric Hematology-Oncology, Istituto di Ricovero e Cura a Carattere Scientifico Ospedale Bambino Gesù, Rome, University of Pavia, Italy

Abstract

Key Points The CBFA2T3-GLIS2 fusion transcript is common in pediatric cytogenetically normal AML and not restricted to FAB M7 subtype. The CBFA2T3-GLIS2 fusion transcript is associated with poor prognosis in pediatric patients with AML.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/121/17/3469/1365192/3469.pdf

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5. Presence of FLT3-ITD and high BAALC expression are independent prognostic markers in childhood acute myeloid leukemia.;Staffas;Blood,2011

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