Presence of FLT3-ITD and high BAALC expression are independent prognostic markers in childhood acute myeloid leukemia

Author:

Staffas Anna1,Kanduri Meena2,Hovland Randi3,Rosenquist Richard2,Ommen Hans Beier4,Abrahamsson Jonas5,Forestier Erik6,Jahnukainen Kirsi7,Jónsson Ólafur G.8,Zeller Bernward9,Palle Josefine10,Lönnerholm Gudmar10,Hasle Henrik11,Palmqvist Lars1,Ehrencrona Hans212,

Affiliation:

1. Department of Clinical Chemistry and Transfusion Medicine, University of Gothenburg, Gothenburg, Sweden;

2. Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden;

3. Center of Medical Genetics and Molecular Medicine, Haukeland University Hospital, Bergen, Norway;

4. Laboratory of Immunohematology, Department of Hematology, Aarhus University Hospital, Aarhus, Denmark;

5. Department of Pediatrics, Sahlgrenska University Hospital, Gothenburg, Sweden;

6. Department of Medical Biosciences, Umeå University, Umeå, Sweden;

7. Department of Pediatrics, University Central Hospital of Helsinki, Helsinki, Finland;

8. Department of Pediatrics, University Hospital, Reykjavik, Iceland;

9. Department of Pediatrics, Oslo University Hospital, Oslo, Norway;

10. Department of Women's and Children's Health, University Children's Hospital, Uppsala, Sweden;

11. Department of Pediatrics, Aarhus University Hospital Skejby, Aarhus, Denmark; and

12. Department of Clinical Genetics, Lund University, Lund, Sweden

Abstract

Abstract Mutation status of FLT3, NPM1, CEBPA, and WT1 genes and gene expression levels of ERG, MN1, BAALC, FLT3, and WT1 have been identified as possible prognostic markers in acute myeloid leukemia (AML). We have performed a thorough prognostic evaluation of these genetic markers in patients with pediatric AML enrolled in the Nordic Society of Pediatric Hematology and Oncology (NOPHO) 1993 or NOPHO 2004 protocols. Mutation status and expression levels were analyzed in 185 and 149 patients, respectively. Presence of FLT3-internal tandem duplication (ITD) was associated with significantly inferior event-free survival (EFS), whereas presence of an NPM1 mutation in the absence of FLT3-ITD correlated with significantly improved EFS. Furthermore, high levels of ERG and BAALC transcripts were associated with inferior EFS. No significant correlation with survival was seen for mutations in CEBPA and WT1 or with gene expression levels of MN1, FLT3, and WT1. In multivariate analysis, the presence of FLT3-ITD and high BAALC expression were identified as independent prognostic markers of inferior EFS. We conclude that analysis of the mutational status of FLT3 and NPM1 at diagnosis is important for prognostic stratification of patients with pediatric AML and that determination of the BAALC gene expression level can add valuable information.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3