CD44 regulates the apoptotic response and promotes disease development in chronic lymphocytic leukemia

Author:

Fedorchenko Oleg1,Stiefelhagen Marius1,Peer-Zada Abdul A.1,Barthel Romy1,Mayer Petra1,Eckei Laura1,Breuer Alexandra1,Crispatzu Giuliano1,Rosen Natascha1,Landwehr Thomas1,Lilienthal Nils1,Möllmann Michael2,Montesinos-Rongen Manuel3,Heukamp Lukas4,Dürig Jan2,Hallek Michael1,Fingerle-Rowson Günter1,Herling Marco1

Affiliation:

1. Department I of Internal Medicine, Center for Integrated Oncology Cologne-Bonn, and Cluster of Excellence, Cellular Stress Responses in Aging-Associated Diseases, University of Cologne, Cologne, Germany;

2. Clinic of Hematology, University Hospital of Essen, Essen, Germany;

3. Institute of Neuropathology, University of Cologne, Cologne, Germany; and

4. Institute of Pathology, University Hospital Cologne, Cologne, Germany

Abstract

Key PointsCD44 expression in CLL is micromilieu instructed and promotes leukemic cell survival, which can be antagonized by CD44 antibodies. As a surface coreceptor, CD44 supports leukemogenesis by modulating stimuli of MCL1 expression (eg, B-cell receptor signals).

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

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