Tumor cells in multiple myeloma patients inhibit myeloma-reactive T cells through carcinoembryonic antigen-related cell adhesion molecule-6

Author:

Witzens-Harig Mathias1,Hose Dirk12,Jünger Simone23,Pfirschke Christina23,Khandelwal Nisit23,Umansky Ludmila3,Seckinger Anja1,Conrad Heinke45,Brackertz Bettina4,Rème Thierry678,Gueckel Brigitte9,Meißner Tobias1,Hundemer Michael1,Ho Anthony D.1,Rossi Jean-Francois68,Neben Kai1,Bernhard Helga410,Goldschmidt Hartmut12,Klein Bernard678,Beckhove Philipp23

Affiliation:

1. Department of Hematology/Oncology, University Hospital of Heidelberg, Heidelberg, Germany;

2. Nationales Centrum für Tumorerkrankungen, Heidelberg, Germany;

3. Translational Immunology Division, German Cancer Research Center, Deutsches Krebsforschungszentrum, Heidelberg, Germany;

4. Department of Hematology/Oncology, Klinikum rechts der Isar, Technische Universität, München, Munich, Germany;

5. Division of Immunogenetics, German Cancer Research Center, Heidelberg, Germany;

6. Institut National de la Santé et de la Recherche Médicale 1040, U1040, Montpellier, France;

7. Centre Hospitalier Universitaire Montpellier, Institute of Research in Biotherapy, Montpellier, France;

8. Université Montpellier 1, Unité de Formation et de Recherche Médecine, Montpellier, France;

9. Department of Gynecology and Obstetrics, University Hospital of Tübingen, Germany; and

10. Department of Hematology/Oncology, Klinikum Darmstadt Gesellschaft mit beschränkter Haftung, Darmstadt, Germany

Abstract

Key Points Multiple myeloma cells inhibit myeloma-specific T cells through expression of carcinoembryonic antigen-related cell adhesion molecule-6.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

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