CEACAM6 expression and function in tumor biology: a comprehensive review-Reference-Cited by-同舟云学术

CEACAM6 expression and function in tumor biology: a comprehensive review

Published:2024-05-25 Issue:1 Volume:15 Page:
ISSN:2730-6011
Container-title:Discover Oncology
language:en
Short-container-title:Discov Onc

Author:

Zhao Dong,Cai Fei,Liu Xuefei,Li Tingting,Zhao Ershu,Wang Xinlong,Zheng Zhendong

Abstract

AbstractCarcinoembryonic antigen-related cell adhesion molecule 6 (CEACAM6) is an immunoglobulin superfamily protein primarily expressed on epithelial surfaces and myeloid cells. It plays a significant role in cancer progression by inhibiting apoptosis, promoting drug resistance, and facilitating cancer cell invasion and metastasis. Overexpression of CEACAM6 has been observed in various cancers, including lung, breast, colorectal, and hepatocellular cancers, and is associated with poorer overall survival and disease-free survival. Its differential expression on tumor cell surfaces makes it a promising cancer marker. This review aims to provide a comprehensive summary of CEACAM6’s role in different cancer types, its involvement in signaling pathways, and recent advancements in CEACAM6-targeted treatments.

Publisher

Springer Science and Business Media LLC

Link

https://link.springer.com/content/pdf/10.1007/s12672-024-01053-6.pdf

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