Early-onset Evans syndrome, immunodeficiency, and premature immunosenescence associated with tripeptidyl-peptidase II deficiency-Reference-Cited by-同舟云学术

Early-onset Evans syndrome, immunodeficiency, and premature immunosenescence associated with tripeptidyl-peptidase II deficiency

Published:2015-01-29 Issue:5 Volume:125 Page:753-761
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Stepensky Polina¹,Rensing-Ehl Anne²,Gather Ruth²³,Revel-Vilk Shoshana¹,Fischer Ute⁴,Nabhani Schafiq⁴,Beier Fabian⁵,Brümmendorf Tim H.⁵,Fuchs Sebastian²³,Zenke Simon²,Firat Elke⁶,Pessach Vered Molho⁷,Borkhardt Arndt⁴,Rakhmanov Mirzokhid²,Keller Bärbel²,Warnatz Klaus²,Eibel Hermann²,Niedermann Gabriele⁶,Elpeleg Orly⁸,Ehl Stephan²⁹

Affiliation:

1. Pediatric Hemato-Oncology and Bone Marrow Transplantation Department, Hadassah-Hebrew University Medical Center, Jerusalem, Israel;

2. Center for Chronic Immunodeficiency, University Medical Center Freiburg and

3. Faculty of Biology, University of Freiburg, Freiburg, Germany;

4. Department of Pediatric Oncology, Hematology, and Clinical Immunology, University Children’s Hospital, Medical Faculty, Heinrich-Heine-University, Düsseldorf, Germany;

5. Department of Hematology, Oncology, and Stem Cell Transplantation, Rheinisch Westfälische Technische Hochschule Aachen University Medical School, Aachen, Germany;

6. Department of Radiation Oncology, University Hospital Freiburg, Freiburg, Germany;

7. Department of Dermatology, Hadassah-Hebrew University Medical Center, Jerusalem, Israel;

8. Monique and Jacques Roboh Department of Genetic Research, Hadassah-Hebrew University Medical Center, Jerusalem, Israel; and

9. Center for Paediatrics and Adolescent Medicine, University Medical Center, University of Freiburg, Germany

Abstract

Key Points Deficiency of TPP2 is associated with Evans syndrome and viral infection susceptibility. TPP2 deficiency links premature immunosenescence of T and B cells with severe autoimmunity.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/125/5/753/1388330/753.pdf

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4. Sequential decisions on FAS sequencing guided by biomarkers in patients with lymphoproliferation and autoimmune cytopenia.;Rensing-Ehl;Haematologica,2013

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