von Willebrand factor fibers promote cancer-associated platelet aggregation in malignant melanoma of mice and humans

Author:

Bauer Alexander T.1,Suckau Jan1,Frank Kathrin2,Desch Anna1,Goertz Lukas1,Wagner Andreas H.3,Hecker Markus3,Goerge Tobias4,Umansky Ludmila5,Beckhove Philipp5,Utikal Jochen2,Gorzelanny Christian1,Diaz-Valdes Nancy26,Umansky Viktor2,Schneider Stefan W.1

Affiliation:

1. Experimental Dermatology, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany;

2. Skin Cancer Unit, German Cancer Research Center (DKFZ), Heidelberg and Department of Dermatology, Venereology and Allergology, University Medical Center Mannheim, Ruprecht-Karl University of Heidelberg, Mannheim, Germany;

3. Institute of Physiology and Pathophysiology, University of Heidelberg, Heidelberg, Germany;

4. Department of Dermatology, University of Muenster, Muenster, Germany;

5. Department of Translational Immunology, German Cancer Research Center (DKFZ), Heidelberg, Germany; and

6. Division of Hepatology and Gene Therapy, Center for Applied Medical Research, University of Navarra, Pamplona, Spain

Abstract

Key Points Tumor-derived VEGF-A mediates endothelial cell activation, VWF release, and platelet aggregation provoking coagulation in tumor patients. Local ADAMTS13 inhibition promotes VWF fiber formation in tumor microvessels.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

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