A dual role for Hdac1: oncosuppressor in tumorigenesis, oncogene in tumor maintenance-Reference-Cited by-同舟云学术

A dual role for Hdac1: oncosuppressor in tumorigenesis, oncogene in tumor maintenance

Published:2013-04-25 Issue:17 Volume:121 Page:3459-3468
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Santoro Fabio¹,Botrugno Oronza A.¹,Dal Zuffo Roberto¹,Pallavicini Isabella¹,Matthews Geoffrey M.²,Cluse Leonie²,Barozzi Iros¹,Senese Silvia¹,Fornasari Lorenzo¹,Moretti Simona¹,Altucci Lucia³,Pelicci Pier Giuseppe¹⁴,Chiocca Susanna¹,Johnstone Ricky W.²⁵,Minucci Saverio¹⁶

Affiliation:

1. Department of Experimental Oncology at the IFOM-IEO Campus, European Institute of Oncology, Milan, Italy;

2. Gene Regulation Laboratory, Cancer Therapeutics Program, Peter MacCallum Cancer Institute, St. Andrews Place, Victoria, Australia;

3. Dipartimento di Patologia Generale, Seconda Universita‘ degli Studi di Napoli, Napoli, Italy;

4. Dipartimento di Medicina, Chirurgia e Odontoiatria, University of Milan, Milan, Italy;

5. The Sir Peter MacCallum Department of Oncology, University of Melbourne, Victoria, Australia; and

6. Department of Biosciences, University of Milan, Milan, Italy

Abstract

Key Points Hdac1 and, to a lesser extent, Hdac2 behave as oncosuppressors during tumor initiation, but they work as oncogenes in tumor maintenance. Class I HDAC inhibitors (VPA) accelerate tumorigenesis in murine models of leukemia, which suggests caution in their clinical use.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/121/17/3459/1364964/3459.pdf

Reference43 articles.

1. The epigenomics of cancer.;Jones;Cell,2007

2. Histone deacetylase inhibitors as a new weapon in the arsenal of differentiation therapies of cancer.;Botrugno;Cancer Lett,2009

3. The many roles of histone deacetylases in development and physiology: implications for disease and therapy.;Haberland;Nat Rev Genet,2009

4. The Rpd3/Hda1 family of lysine deacetylases: from bacteria and yeast to mice and men.;Yang;Nat Rev Mol Cell Biol,2008

5. Genetic dissection of histone deacetylase requirement in tumor cells.;Haberland;Proc Natl Acad Sci USA,2009

Cited by 107 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. A Novel Class I HDAC Inhibitor, AW01178, Inhibits Epithelial–Mesenchymal Transition and Metastasis of Breast Cancer;International Journal of Molecular Sciences;2024-06-30

2. HDAC1 acts as tumor suppressor in ALK-positive anaplastic large-cell lymphoma: Implications for HDAC inhibitor therapy;2024-06-03

3. Dysregulation of histone deacetylases in ocular diseases;Archives of Pharmacal Research;2023-12-27

4. HDAC inhibitors: Promising agents for leukemia treatment;Biochemical and Biophysical Research Communications;2023-11

5. Advances in acute myeloid leukemia differentiation therapy: A critical review;Biochemical Pharmacology;2023-09