Bortezomib inhibits STAT5-dependent degradation of LEF-1, inducing granulocytic differentiation in congenital neutropenia CD34+ cells-Reference-Cited by-同舟云学术

Bortezomib inhibits STAT5-dependent degradation of LEF-1, inducing granulocytic differentiation in congenital neutropenia CD34+ cells

Published:2014-04-17 Issue:16 Volume:123 Page:2550-2561
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Gupta Kshama¹,Kuznetsova Inna¹,Klimenkova Olga¹,Klimiankou Maksim¹,Meyer Johann²,Moore Malcolm A. S.³,Zeidler Cornelia¹,Welte Karl¹,Skokowa Julia¹

Affiliation:

1. Department of Molecular Hematopoiesis, and

2. Department of Experimental Hematology, Hannover Medical School, Hannover, Germany; and

3. Cell Biology Program, Sloan-Kettering Institute, New York, NY

Abstract

Key Points Hyperactivated STAT5a binds LEF-1 protein leading to NLK/NARF/ubiquitin-dependent degradation of LEF-1 followed by defective granulopoiesis. In CN patients, elevated levels of phospho-STAT5a resulted in diminished LEF-1 expression, which could be restored by bortezomib treatment.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/123/16/2550/1376211/2550.pdf

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