Bacterial lipopolysaccharide fever is initiated via Toll-like receptor 4 on hematopoietic cells-Reference-Cited by-同舟云学术

Bacterial lipopolysaccharide fever is initiated via Toll-like receptor 4 on hematopoietic cells

Published:2006-05-15 Issue:10 Volume:107 Page:4000-4002
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Steiner Alexandre A.¹,Chakravarty Sumana¹,Rudaya Alla Y.¹,Herkenham Miles¹,Romanovsky Andrej A.¹

Affiliation:

1. From the Systemic Inflammation Laboratory, Trauma Research, St Joseph's Hospital and Medical Center, Phoenix, AZ; and Section on Functional Neuroanatomy, National Institute of Mental Health, National Institutes of Health, Bethesda, MD.

Abstract

Lipopolysaccharide (LPS), a well-known bacterial pyrogen, is recognized by several receptors, including the Toll-like receptor 4 (TLR4), on various cells. Which of these receptors and cells are linked to fever production is unknown. By constructing 4 mouse chimeras and studying their thermoregulatory responses, we found that all 3 phases of the typical LPS fever depend on TLR4 signaling. The first phase is triggered via the TLR4 on hematopoietic cells. The second and third phases involve TLR4 signaling in both hematopoietic and nonhematopoietic cells.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/107/10/4000/466419/zh801006004000.pdf

Reference19 articles.

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