Impact of CTLA4 genotype and other immune response gene polymorphisms on outcomes after single umbilical cord blood transplantation

Author:

Cunha Renato1234,Zago Marco A.4,Querol Sergio5,Volt Fernanda123,Ruggeri Annalisa1236,Sanz Guillermo7,Pouthier Fabienne8,Kogler Gesine9,Vicario José L.10,Bergamaschi Paola111213,Saccardi Riccardo14,Lamas Carmen H.15,Díaz-de-Heredia Cristina16,Michel Gerard17,Bittencourt Henrique18,Tavella Marli4,Panepucci Rodrigo A.4,Fernandes Francisco19,Pavan Julia19,Gluckman Eliane123,Rocha Vanderson1232021

Affiliation:

1. Eurocord, Hôpital Saint Louis, Assistance Publique–Hôpitaux de Paris (AP-HP), Paris, France;

2. University Paris-Diderot, Paris, France;

3. Monacord, Centre Scientifique de Monaco, Monaco;

4. Clinical Hospital, Ribeirão Preto School of Medicine, São Paulo University, Ribeirão Preto, Brazil;

5. Barcelona Cord Blood Bank, Barcelona, Spain;

6. Service d’Hématologie et Thérapie Cellulaire, Hôpital Saint Antoine, AP-HP, Paris, France;

7. La Fe University Hospital, Valencia, Spain;

8. Besançon Cord Blood Bank, Besançon, France;

9. José Carreras Cord Blood Bank, Düsseldorf, Germany;

10. Madrid Cord Blood Bank, Madrid, Spain;

11. Pavia Cord Blood Bank, Pavia, Italy;

12. Service of Immunohematology and Transfusion Medicine, Policlinico San Matteo, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico, Pavia, Italy;

13. Department of Biology and Biotechnology, University of Pavia, Pavia, Italy;

14. Firenze Cord Blood Bank, Firenze, Italy;

15. Malaga Cord Blood Bank, Malaga, Spain;

16. Vall d’Hebron Hospital, Barcelona, Spain;

17. Timone Children Hospital, Marseille, France;

18. Sainte-Justine University Health Center, Montreal, Canada;

19. Mathematics Institute, São Paulo University, São Paulo, Brazil;

20. Oxford University, Oxford, United Kingdom; and

21. Serviço de Hematologia, Hemoterapia e Terapia Celular, São Paulo University, São Paulo, Brazil

Abstract

Key Points Gene polymorphism of the immune response as CTLA4 was shown to impact CBT outcomes according to CBU genotype. CTLA4-CBU genotype might be considered for CBU selection when >1 CBU meeting the current suggested selection criteria is available.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3