Impact of allele-level HLA matching on outcomes after myeloablative single unit umbilical cord blood transplantation for hematologic malignancy

Author:

Eapen Mary12,Klein John P.13,Ruggeri Annalisa4,Spellman Stephen5,Lee Stephanie J.6,Anasetti Claudio7,Arcese William8,Barker Juliet N.9,Baxter-Lowe Lee Ann10,Brown Maria5,Fernandez-Vina Marcelo A.11,Freeman John12,He Wensheng12,Iori Anna Paola13,Horowitz Mary M.12,Locatelli Franco1415,Marino Susana16,Maiers Martin12,Michel Gerard17,Sanz Guillermo F.18,Gluckman Eliane4,Rocha Vanderson19

Affiliation:

1. Center for International Blood and Marrow Transplant Research,

2. Department of Medicine, and

3. Division of Biostatistics, Medical College of Wisconsin, Milwaukee, WI;

4. Eurocord, Hôpital Saint Louis, Paris, France;

5. Center for International Blood and Marrow Transplant Research, National Marrow Donor Program, Minneapolis, MN;

6. Fred Hutchinson Cancer Research Center, University of Washington, Seattle, WA;

7. H. Lee Moffitt Cancer Center, Tampa, FL;

8. Rome Transplant Network, University Tor Vergata, Rome, Italy;

9. Memorial Sloan-Kettering Cancer Center, New York, NY;

10. University of California, San Francisco, CA;

11. Stanford University, Palo Alto, CA;

12. Bioinformatics, National Marrow Donor Program, Minneapolis, MN;

13. University of Rome, La Sapienza, Rome, Italy;

14. Instituto di Ricovero e Cura a Carattere Scientifico, Ospedale Pediatrico Bambino Gesu, Rome, Italy;

15. University of Pavia, Pavia, Italy;

16. University of Chicago, Chicago, IL;

17. University Hospital of Marseille, Marseille, France;

18. Hospital Universitario La Fe, Valencia, Spain; and

19. Churchill Hospital, Oxford, United Kingdom

Abstract

Key Points Efficacy of transplanting allele-level HLA-matched cord blood units.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

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