Occupancy of human EPCR by protein C induces β-arrestin-2 biased PAR1 signaling by both APC and thrombin-Reference-Cited by-同舟云学术

Occupancy of human EPCR by protein C induces β-arrestin-2 biased PAR1 signaling by both APC and thrombin

Published:2016-10-06 Issue:14 Volume:128 Page:1884-1893
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Roy Ram Vinod¹,Ardeshirylajimi Abdolreza¹,Dinarvand Peyman¹,Yang Likui¹,Rezaie Alireza R.¹

Affiliation:

1. Edward A. Doisy Department of Biochemistry and Molecular Biology, Saint Louis University School of Medicine, Saint Louis, MO

Abstract

Key PointsThrombin and APC elicit paradoxical signaling responses through cleavage of PAR1 at different sites. EPCR occupancy mediates β-arrestin-2 biased protective PAR1 signaling by both proteases via recruiting GRK5 and Dvl-2.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/128/14/1884/1396591/1884.pdf

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4. Molecular recognition in the protein C anticoagulant pathway.;Dahlbäck;J Thromb Haemost,2003

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