Structural and functional properties of thrombomodulin-Reference-Cited by-同舟云学术

Structural and functional properties of thrombomodulin

Published:2024-06-24 Issue:2 Volume:23 Page:198-207
ISSN:2414-9314
Container-title:Pediatric Hematology/Oncology and Immunopathology
language:
Short-container-title:Voprosy gematologii/onkologii i immunopatologii v pediatrii

Author:

Bleskin D. A.¹,Koltsova E. M.²^ORCID,Nechipurenko D. Yu.³

Affiliation:

1. Center for Theoretical Problems of Physical and Chemical Pharmacology, Russian Academy of Sciences; N.M. Emanuel Institute of Biochemical Physics, Russian Academy of Sciences

2. Center for Theoretical Problems of Physical and Chemical Pharmacology, Russian Academy of Sciences; Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and Immunology of Ministry of Healthcare of the Russian Federation

3. Center for Theoretical Problems of Physical and Chemical Pharmacology, Russian Academy of Sciences; Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and Immunology of Ministry of Healthcare of the Russian Federation; M.V. Lomonosov Moscow State University

Abstract

Thrombomodulin (TM) is an integral component of a multimolecular system, localized primarily in the vascular endothelium, and regulating a number of crucial physiological responses of an organism, including blood coagulation and inflammation. This review presents the currently known key functions of TM in the context of its structure. The first part of the review examines the domain structure of the TM molecule and describes the key molecular processes in which the corresponding domains participate. The second part of the review is devoted to a more detailed analysis of the TM molecule participation in the regulation of physiological processes in the human organism. Since the main function of TM is associated with the regulation of the hemostatic response to vascular wall injury, special attention is paid to the role of this molecule in the activation of protein C and thrombin-activated fibrinolysis inhibitor, which is responsible for stopping fibrinolysis. In addition, the review briefly describes some data on the role of TM in the mitogenesis of various cell types and in angiogenesis processes. One section of the review is devoted to the current knowledge of TM participation in the regulation of inflammatory reactions of the body. This section describes the key mechanisms through which TM is able to limit the level of pro-inflammatory signals, as well as regulate the processes of complement system activation.

Publisher

Fund Doctors, Innovations, Science for Children

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