An oxidative stress-based mechanism of doxorubicin cytotoxicity suggests new therapeutic strategies in ABC-DLBCL-Reference-Cited by-同舟云学术

An oxidative stress-based mechanism of doxorubicin cytotoxicity suggests new therapeutic strategies in ABC-DLBCL

Published:2016-12-15 Issue:24 Volume:128 Page:2797-2807
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Mai Yun¹,Yu J. Jessica¹,Bartholdy Boris¹,Xu-Monette Zijun Y.²,Knapp Esther E.³⁴,Yuan Fei¹,Chen Hongshan¹,Ding B. Belinda¹,Yao Zhihua²,Das Bhaskar⁵,Zou Yiyu⁶,Young Ken He²,Parekh Samir¹⁶,Ye B. Hilda¹^ORCID

Affiliation:

1. Department of Cell Biology, Albert Einstein College of Medicine and Montefiore Medical Center, Bronx, New York, NY;

2. Department of Hematopathology, The University of Texas MD Anderson Cancer Center, Houston, TX;

3. Department of Pediatrics,

4. The Children’s Hospital at Montefiore,

5. Department of Nuclear Medicine, and

6. Department of Medicine, Albert Einstein College of Medicine and Montefiore Medical Center, Bronx, New York, NY

Abstract

Key Points Dox causes DNA damage inefficiently in ABC-DLBCL because of preferential cytoplasmic localization. STAT3 promotes resistance to ROS-mediated Dox cytotoxicity by upregulating the expression of SOD2.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/128/24/2797/1358139/blood705814.pdf

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