Deep phenotyping of Tregs identifies an immune signature for idiopathic aplastic anemia and predicts response to treatment-Reference-Cited by-同舟云学术

Deep phenotyping of Tregs identifies an immune signature for idiopathic aplastic anemia and predicts response to treatment

Published:2016-09-01 Issue:9 Volume:128 Page:1193-1205
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Kordasti Shahram¹²^ORCID,Costantini Benedetta¹²,Seidl Thomas¹,Perez Abellan Pilar²,Martinez Llordella Marc³,McLornan Donal²,Diggins Kirsten E.⁴,Kulasekararaj Austin²,Benfatto Cinzia¹,Feng Xingmin⁵,Smith Alexander¹²,Mian Syed A.¹,Melchiotti Rossella⁶,de Rinaldis Emanuele⁶,Ellis Richard⁶,Petrov Nedyalko⁶,Povoleri Giovanni A. M.³,Chung Sun Sook¹,Thomas N. Shaun B.¹,Farzaneh Farzin¹,Irish Jonathan M.⁴,Heck Susanne⁶,Young Neal S.⁵,Marsh Judith C. W.¹²,Mufti Ghulam J.¹²

Affiliation:

1. Department of Haematological Medicine, King's College London, London, United Kingdom;

2. Haematological Medicine, King's College Hospital, London, United Kingdom;

3. Division of Transplantation Immunology & Mucosal Biology, King's College London, London, United Kingdom;

4. Department of Cancer Biology, Vanderbilt University, Nashville, TN;

5. Hematology Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD; and

6. National Institute for Health Research Biomedical Research Centre, King's College London, London, United Kingdom

Abstract

Key Points Mass cytometry reveals a Treg immune signature for AA and for response to antithymocyte globulin. AA Tregs in vitro are expandable, stable, and functional, with potential for future therapeutic options.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/128/9/1193/1399107/1193.pdf

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