Eltrombopag restores trilineage hematopoiesis in refractory severe aplastic anemia that can be sustained on discontinuation of drug

Author:

Desmond Ronan1,Townsley Danielle M.1,Dumitriu Bogdan1,Olnes Matthew J.2,Scheinberg Phillip3,Bevans Margaret4,Parikh Ankur R.1,Broder Kinneret1,Calvo Katherine R.5,Wu Colin O.6,Young Neal S.1,Dunbar Cynthia E.1

Affiliation:

1. Hematology Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD;

2. Hematology Department, Alaska Native Tribal Health Consortium, Anchorage, AK;

3. Hospital Sao Jose – Hospital Beneficencia Portuguesa de Sao Paulo, Sao Paulo, Brazil;

4. Nursing Research and Translational Science, National Institutes of Health, Bethesda, MD;

5. Laboratory Medicine, National Institutes of Health, Bethesda, MD; and

6. Office of Biostatistics Research, National Heart, Lung, and Blood Institute, Bethesda, MD

Abstract

Key Points Eltrombopag promotes hematopoiesis in patients with severe aplastic anemia by stimulating stem and progenitor cells. Eltrombopag can be discontinued safely in robust responders with maintenance of hematopoiesis.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

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