Prothrombotic skeletal muscle myosin directly enhances prothrombin activation by binding factors Xa and Va-Reference-Cited by-同舟云学术

Prothrombotic skeletal muscle myosin directly enhances prothrombin activation by binding factors Xa and Va

Published:2016-10-06 Issue:14 Volume:128 Page:1870-1878
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Deguchi Hiroshi¹,Sinha Ranjeet K.¹,Marchese Patrizia¹,Ruggeri Zaverio M.¹,Zilberman-Rudenko Jevgenia²,McCarty Owen J. T.²,Cohen Mitchell J.³,Griffin John H.¹⁴

Affiliation:

1. Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA;

2. Biomedical Engineering, School of Medicine and Division of Hematology, Oregon Health and Science University, Portland, OR;

3. Department of Surgery, University of California, San Francisco and San Francisco General Hospital, San Francisco, CA; and

4. Division of Hematology, Department of Medicine, University of California, San Diego, La Jolla, CA

Abstract

Key Points Skeletal muscle myosin promotes thrombus formation and enhances prothrombin activation by binding factors Xa and Va. The procoagulant activity of skeletal muscle myosin might contribute to the hypercoagulability in plasmas of acute trauma patients.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/128/14/1870/1396322/1870.pdf

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