New insights into the spatiotemporal localization of prothrombinase in vivo-Reference-Cited by-同舟云学术

New insights into the spatiotemporal localization of prothrombinase in vivo

Published:2014-09-11 Issue:11 Volume:124 Page:1705-1714
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Ivanciu Lacramioara¹²,Krishnaswamy Sriram¹³,Camire Rodney M.¹²³

Affiliation:

1. The Children's Hospital of Philadelphia,

2. The Center for Cell and Molecular Therapeutics, and

3. Division of Hematology, Department of Pediatrics, The University of Pennsylvania, Perelman School of Medicine, Philadelphia, PA

Abstract

Key Points Prothrombinase bound in the vicinity of vascular damage is distributed away from platelets and is largely found on activated endothelium. The activated endothelium plays an unexpectedly important role in supporting prothrombinase assembly and function at the site of damage.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/124/11/1705/1468879/1705.pdf

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