Histone deacetylase 1 and 2 are essential for normal T-cell development and genomic stability in mice-Reference-Cited by-同舟云学术

Histone deacetylase 1 and 2 are essential for normal T-cell development and genomic stability in mice

Published:2013-02-21 Issue:8 Volume:121 Page:1335-1344
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Dovey Oliver M.¹²,Foster Charles T.³,Conte Nathalie⁴,Edwards Sally A.⁵,Edwards Jennifer M.⁶,Singh Rajinder⁷,Vassiliou George²,Bradley Allan²,Cowley Shaun M.¹

Affiliation:

1. Department of Biochemistry, University of Leicester, Leicester, United Kingdom;

2. The Wellcome Trust Sanger Institute, Cambridge, United Kingdom;

3. Transcription Laboratory, Cancer Research UK London Research Institute, London, United Kingdom;

4. Functional Genomics Team, European Molecular Biology Laboratory–European Bioinformatics Institute, Cambridge, United Kingdom;

5. Bio Services Unit, Queens Medical Centre, Nottingham, United Kingdom;

6. Medical Research Council Toxicology Unit, University of Leicester, Leicester, United Kingdom; and

7. Cancer Biomarkers and Prevention Group, Biocentre, Department of Cancer Studies and Molecular Medicine, University of Leicester, Leicester, United Kingdom

Abstract

Key PointsWe demonstrate a critical role for histone deacetylase 1 and 2 (HDAC1/2) in T-cell development and the maintenance of genomic stability.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/121/8/1335/1369209/zh800813001335.pdf

Reference50 articles.

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2. Histone deacetylases 1 and 2 redundantly regulate cardiac morphogenesis, growth, and contractility.;Montgomery;Genes Dev,2007

3. Histone deacetylases 1 and 2 control the progression of neural precursors to neurons during brain development.;Montgomery;Proc Natl Acad Sci U S A,2009