CC chemokine receptor 8 potentiates donor Treg survival and is critical for the prevention of murine graft-versus-host disease-Reference-Cited by-同舟云学术

CC chemokine receptor 8 potentiates donor Treg survival and is critical for the prevention of murine graft-versus-host disease

Published:2013-08-01 Issue:5 Volume:122 Page:825-836
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Coghill James M.¹²,Fowler Kenneth A.²,West Michelle L.²,Fulton LeShara M.¹²,van Deventer Hendrik¹²,McKinnon Karen P.²,Vincent Benjamin G.¹²,Lin Kaifeng²,Panoskaltsis-Mortari Angela³,Cook Donald N.⁴,Blazar Bruce R.³,Serody Jonathan S.¹²

Affiliation:

1. Department of Medicine and

2. Immunotherapy Program, Lineberger Comprehensive Cancer Center, University of North Carolina School of Medicine, Chapel Hill, NC;

3. The University of Minnesota Cancer Center, Minneapolis, MN; and

4. The National Institute of Environmental Health Sciences, Durham, NC

Abstract

Key Points Extended donor Treg survival is required for protection from GVHD; donor Treg longevity depends on Treg CCR8 expression. Donor CD11c+ APCs promote Treg longevity in vivo; host CD11c+ APCs do not appear to contribute to donor Treg reconstitution.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/122/5/825/1374449/825.pdf

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