USP22 deficiency leads to myeloid leukemia upon oncogenic Kras activation through a PU.1-dependent mechanism-Reference-Cited by-同舟云学术

USP22 deficiency leads to myeloid leukemia upon oncogenic Kras activation through a PU.1-dependent mechanism

Published:2018-07-26 Issue:4 Volume:132 Page:423-434
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Melo-Cardenas Johanna¹^ORCID,Xu Yuanming¹,Wei Juncheng¹,Tan Can¹,Kong Sinyi¹,Gao Beixue¹,Montauti Elena¹,Kirsammer Gina²³,Licht Jonathan D.⁴⁵,Yu Jindan²³,Ji Peng¹,Crispino John D.²³,Fang Deyu¹

Affiliation:

1. Department of Pathology,

2. Department of Hematology and Oncology, and

3. Department of Biochemistry and Molecular Genetics, Northwestern University Feinberg School of Medicine, Chicago, IL; and

4. Department of Medicine and

5. Department of Biochemistry and Molecular Biology, University of Florida Health Cancer Center, Gainesville, FL

Abstract

Key Points USP22 deficiency in Ras-driven myeloproliferative neoplasm blocks myeloid differentiation promoting acute myeloid leukemia. USP22 is a PU.1 deubiquitylase that positively regulates PU.1 stability and the expression of myeloid-differentiation genes.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/132/4/423/1407469/blood811760.pdf

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