Affiliation:
1. Department of Biotechnology and Biosciences University of Milano‐Bicocca 20126 Milan Italy
Abstract
Hematopoietic stem cells (HSC) maintain blood production throughout life. Nevertheless, HSC functionality deteriorates upon physiological aging leading to the increased prevalence of haematological diseases and hematopoietic malignancies in the elderly. Deubiquitinating enzymes (DUBs) by reverting protein ubiquitination ensure proper proteostasis, a key process in HSC maintenance and fitness.
Funder
H2020 Marie Skłodowska-Curie Actions