CC-122, a pleiotropic pathway modifier, mimics an interferon response and has antitumor activity in DLBCL-Reference-Cited by-同舟云学术

CC-122, a pleiotropic pathway modifier, mimics an interferon response and has antitumor activity in DLBCL

Published:2015-08-06 Issue:6 Volume:126 Page:779-789
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Hagner Patrick R.¹,Man Hon-Wah¹,Fontanillo Celia²,Wang Maria³,Couto Suzana³,Breider Mike³,Bjorklund Chad¹,Havens Courtney G.³,Lu Gang³,Rychak Emily³,Raymon Heather³,Narla Rama Krishna³,Barnes Leo³,Khambatta Gody³,Chiu Hsiling¹,Kosek Jolanta¹,Kang Jian¹,Amantangelo Michael D.¹,Waldman Michelle¹,Lopez-Girona Antonia³,Cai Ti¹,Pourdehnad Michael⁴,Trotter Matthew²,Daniel Thomas O.³,Schafer Peter H.¹,Klippel Anke¹,Thakurta Anjan¹,Chopra Rajesh¹,Gandhi Anita K.¹

Affiliation:

1. Celgene Corporation, Summit, NJ;

2. Celgene Corporation, Sevilla, Spain;

3. Celgene Corporation, San Diego, CA; and

4. Celgene Corporation, San Francisco, CA

Abstract

Key Points CC-122 is a novel agent for DLBCL with antitumor and immunomodulatory activity. CC-122 binds CRBN and degrades Aiolos and Ikaros resulting in a mimicry of IFN signaling and apoptosis in DLBCL.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/126/6/779/1391360/779.pdf

Reference36 articles.

1. New approach to classifying non-Hodgkin’s lymphomas: clinical features of the major histologic subtypes. Non-Hodgkin’s Lymphoma Classification Project.;Armitage;J Clin Oncol,1998

2. Prognostic factors for diffuse large B-cell lymphoma in the R(X)CHOP era.;Vaidya;Ann Oncol,2014

3. Long-term results of the R-CHOP study in the treatment of elderly patients with diffuse large B-cell lymphoma: a study by the Groupe d’Etude des Lymphomes de l’Adulte.;Feugier;J Clin Oncol,2005

4. Distinct types of diffuse large B-cell lymphoma identified by gene expression profiling.;Alizadeh;Nature,2000

5. Determining cell-of-origin subtypes of diffuse large B-cell lymphoma using gene expression in formalin-fixed paraffin-embedded tissue.;Scott;Blood,2014

Cited by 151 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Immunomodulation and anticancer evaluation of quinazoline-based thalidomide analogs: Design, synthesis, docking, and dynamic simulation;Journal of Molecular Structure;2024-12

2. Inducing or enhancing protein-protein interaction to develop drugs: Molecular glues with various biological activity;European Journal of Medicinal Chemistry;2024-11

3. Targeted protein degradation in hematologic malignancies: clinical progression towards novel therapeutics;Biomarker Research;2024-08-21

4. Transcriptomic classification of diffuse large B-cell lymphoma identifies a high-risk activated B-cell-like subpopulation with targetable MYC dysregulation;Nature Communications;2024-08-08

5. Targeting the ubiquitin pathway in lymphoid malignancies;Cancer Letters;2024-07