Determining cell-of-origin subtypes of diffuse large B-cell lymphoma using gene expression in formalin-fixed paraffin-embedded tissue

Author:

Scott David W.1,Wright George W.2,Williams P. Mickey3,Lih Chih-Jian3,Walsh William3,Jaffe Elaine S.4,Rosenwald Andreas5,Campo Elias6,Chan Wing C.7,Connors Joseph M.1,Smeland Erlend B.8,Mottok Anja1,Braziel Rita M.9,Ott German10,Delabie Jan11,Tubbs Raymond R.12,Cook James R.13,Weisenburger Dennis D.14,Greiner Timothy C.7,Glinsmann-Gibson Betty J.15,Fu Kai7,Staudt Louis M.16,Gascoyne Randy D.117,Rimsza Lisa M.15

Affiliation:

1. Centre for Lymphoid Cancer, British Columbia Cancer Agency, Vancouver, BC, Canada;

2. Biometric Research Branch, Division of Cancer Treatment and Diagnosis, National Cancer Institute, Bethesda, MD;

3. Molecular Characterization Laboratory, Leidos Medical Research Inc., Frederick National Laboratory for Cancer Research, Frederick, MD;

4. Laboratory of Pathology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD;

5. Institute of Pathology, University of Wuerzburg, Wuerzburg, Germany;

6. Department of Pathology, Hospital Clínic, Barcelona, Spain;

7. Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE;

8. Department of Immunology and Centre for Cancer Biomedicine, University of Oslo and Oslo University Hospital, Oslo, Norway;

9. Department of Pathology, Oregon Health and Sciences University, Portland, OR;

10. Department of Clinical Pathology, Robert-Bosch-Krankenhaus and Dr. Margarete Fischer-Bosch Institute of Clinical Pharmacology, Stuttgart, Germany;

11. Oslo University Hospital, Oslo, Norway;

12. Clinical Pathology, Cleveland Clinic Foundation, Cleveland, OH;

13. Department of Molecular Pathology and Laboratory Medicine, Cleveland Clinic, Cleveland, OH;

14. Department of Pathology, City of Hope, Duarte, CA;

15. Department of Pathology, University of Arizona, Tucson, AZ;

16. Metabolism Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD; and

17. Department of Pathology, British Columbia Cancer Agency, Vancouver, BC, Canada

Abstract

Key Points A 20-gene gene expression-based assay accurately and robustly assigns COO subtypes of DLBCL using formalin-fixed paraffin-embedded tissue.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Reference22 articles.

1. World Health Organization Classification of Tumours of Haematopoietic and Lymphoid Tissues;Swerdlow,2008

2. Distinct types of diffuse large B-cell lymphoma identified by gene expression profiling.;Alizadeh;Nature,2000

3. A gene expression-based method to diagnose clinically distinct subgroups of diffuse large B cell lymphoma.;Wright;Proc Natl Acad Sci USA,2003

4. Pathogenesis of human B cell lymphomas.;Shaffer;Annu Rev Immunol,2012

5. The use of molecular profiling to predict survival after chemotherapy for diffuse large-B-cell lymphoma.;Rosenwald;N Engl J Med,2002

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