Targetable kinase gene fusions in high-risk B-ALL: a study from the Children’s Oncology Group

Author:

Reshmi Shalini C.12,Harvey Richard C.3ORCID,Roberts Kathryn G.4,Stonerock Eileen1,Smith Amy5,Jenkins Heather1,Chen I-Ming3,Valentine Marc6,Liu Yu7,Li Yongjin7,Shao Ying4,Easton John7,Payne-Turner Debbie4,Gu Zhaohui4,Tran Thai Hoa8,Nguyen Jonathan V.8,Devidas Meenakshi9,Dai Yunfeng9,Heerema Nyla A.2,Carroll Andrew J.10,Raetz Elizabeth A.11,Borowitz Michael J.12,Wood Brent L.13,Angiolillo Anne L.14,Burke Michael J.15,Salzer Wanda L.16,Zweidler-McKay Patrick A.17,Rabin Karen R.18,Carroll William L.19,Zhang Jinghui7,Loh Mignon L.8,Mullighan Charles G.4,Willman Cheryl L.3,Gastier-Foster Julie M.1220,Hunger Stephen P.21

Affiliation:

1. Institute for Genomic Medicine, Nationwide Children’s Hospital, Columbus, OH;

2. Department of Pathology, The Ohio State University College of Medicine, Columbus, OH;

3. University of New Mexico Cancer Center, Albuquerque, NM;

4. Department of Pathology, St. Jude Children’s Research Hospital, Memphis, TN;

5. Comprehensive Cancer Center, The Ohio State University College of Medicine, Columbus, OH;

6. Department of Cytogenetics and

7. Department of Computational Biology, St. Jude Children’s Research Hospital, Memphis, TN;

8. Department of Pediatrics, UCSF Benioff Children’s Hospital and Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, CA;

9. Department of Biostatistics, University of Florida, Gainesville, FL;

10. Department of Genetics, University of Alabama at Birmingham, Birmingham, AL;

11. Department of Pediatrics, University of Utah, Salt Lake City, UT;

12. Department of Pathology, Johns Hopkins University, Baltimore, MD;

13. Seattle Children’s Hospital, Seattle, WA;

14. Children’s National Medical Center, Washington, DC;

15. Department of Pediatrics, Medical College of Wisconsin, Milwaukee, WI;

16. US Army Medical Research and Materiel Command, Fort Detrick, MD;

17. Department of Pediatrics, MD Anderson Cancer Center, Houston, TX;

18. Department of Pediatrics, Baylor College of Medicine, Houston, TX;

19. Perlmutter Cancer Center, NYU Langone Medical Center, New York, NY;

20. Department of Pediatrics, The Ohio State University College of Medicine, Columbus, OH; and

21. Department of Pediatrics, Children’s Hospital of Philadelphia and Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA

Abstract

Key Points Ph-like ALL is characterized by a diverse array of genetic alterations activating cytokine receptor and tyrosine kinase signaling. Pediatric patients with Ph-like ALL can be identified in real time for effective treatment stratification.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

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