A novel integrated cytogenetic and genomic classification refines risk stratification in pediatric acute lymphoblastic leukemia-Reference-Cited by-同舟云学术

A novel integrated cytogenetic and genomic classification refines risk stratification in pediatric acute lymphoblastic leukemia

Published:2014-08-28 Issue:9 Volume:124 Page:1434-1444
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Moorman Anthony V.¹,Enshaei Amir¹,Schwab Claire¹,Wade Rachel²,Chilton Lucy¹,Elliott Alannah¹,Richardson Stacey¹,Hancock Jeremy³,Kinsey Sally E.⁴⁵,Mitchell Christopher D.⁶,Goulden Nicholas⁷,Vora Ajay⁸,Harrison Christine J.¹

Affiliation:

1. Leukaemia Research Cytogenetics Group, Northern Institute for Cancer Research, Newcastle University, Newcastle upon Tyne, United Kingdom;

2. Clinical Trial Service Unit, University of Oxford, Oxford, United Kingdom;

3. Bristol Genetics Laboratory, North Bristol National Health Service Trust, Bristol, United Kingdom;

4. Leeds Institute of Molecular Medicine, University of Leeds, Leeds, United Kingdom;

5. Department of Paediatric Haematology and Oncology, Leeds General Infirmary, Leeds, United Kingdom;

6. Department of Paediatric Oncology, John Radcliffe Hospital, Oxford, United Kingdom;

7. Department of Haematology, Great Ormond Street Hospital, London, United Kingdom; and

8. Department of Haematology, Sheffield Children’s Hospital, Sheffield, United Kingdom

Abstract

Key Points Integrating cytogenetic and genomic data in pediatric ALL reveals 2 subgroups with different outcomes independent of other risk factors. A total of 75% of children on UKALL2003 had a good-risk genetic profile, which predicted an EFS and OS of 94% and 97% at 5 years.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/124/9/1434/1382725/1434.pdf

Reference37 articles.

1. The clinical relevance of chromosomal and genomic abnormalities in B-cell precursor acute lymphoblastic leukaemia.;Moorman;Blood Rev,2012

2. Prognostic effect of chromosomal abnormalities in childhood B-cell precursor acute lymphoblastic leukaemia: results from the UK Medical Research Council ALL97/99 randomised trial.;Moorman;Lancet Oncol,2010

3. Genome-wide analysis of genetic alterations in acute lymphoblastic leukaemia.;Mullighan;Nature,2007

4. Genes commonly deleted in childhood B-cell precursor ALL: association with cytogenetics and clinical features.;Schwab;Haematologica,2013

5. Deletion of IKZF1 and prognosis in acute lymphoblastic leukemia.;Mullighan;N Engl J Med,2009

Cited by 167 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. The landscape of cytogenetic and molecular genetic methods in diagnostics for hematologic neoplasia;Best Practice & Research Clinical Haematology;2024-02

2. The evolution of nutritional care in children and young people with acute lymphoblastic leukaemia: a narrative review;Journal of Human Nutrition and Dietetics;2024-01-07

3. Cytogenetics in the management of hematological malignancies: an overview of alternative technologies for cytogenetic characterization;Current Research in Translational Medicine;2024-01

4. Cytogenetics and genomics in pediatric acute lymphoblastic leukaemia;Best Practice & Research Clinical Haematology;2023-12

5. Prognostic Impact of Copy Number Alterations’ Profile and AID/RAG Signatures in Acute Lymphoblastic Leukemia (ALL) with BCR::ABL and without Recurrent Genetic Aberrations (NEG ALL) Treated with Intensive Chemotherapy;Cancers;2023-11-15