Functional evidence for derivation of systemic histiocytic neoplasms from hematopoietic stem/progenitor cells

Author:

Durham Benjamin H.12,Roos-Weil Damien3,Baillou Claude4,Cohen-Aubart Fleur5,Yoshimi Akihide2,Miyara Makoto46,Papo Matthias5,Hélias-Rodzewicz Zofia78,Terrones Nathalie8,Ozkaya Neval1,Dogan Ahmet1,Rampal Raajit9,Urbain Fanny5,Le Fèvre Lucie5,Diamond Eli L.10,Park Christopher Y.11,Papo Thomas12,Charlotte Frédéric13,Gorochov Guy46,Taly Valérie14,Bernard Olivier A.3,Amoura Zahir5,Abdel-Wahab Omar29,Lemoine François M.4,Haroche Julien5,Emile Jean-François78ORCID

Affiliation:

1. Department of Pathology and

2. Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY;

3. Unité Mixte de Recherche (UMR)1170, INSERM and Institut Gustave Roussy, Villejuif, France;

4. Sorbonne Universités, UPMC/Paris 06, UMR-S INSERM U1135, Centre National de la Recherche (CNRS) ERL 8255, Centre d’Immunologie et Maladies Infectieuses, Paris, France;

5. Assistance Publique–Hôpitaux de Paris (AP-HP), University Hospital La Pitié-Salpêtrière, Department of Internal Medicine, Centre de Référence des Histiocytoses, Paris, France;

6. Department of Immunology, AP-HP Pitié Salpêtrière, Paris, France;

7. EA4340, Versailles University, Paris-Saclay University, Boulogne, France;

8. Pathology Service, Hôpital Universitaire Ambroise Paré, AP-HP, Boulogne, France;

9. Leukemia Service, Department of Medicine, and

10. Department of Neurology, Memorial Sloan Kettering Cancer Center, New York, NY;

11. Department of Pathology, New York University School of Medicine, New York, NY;

12. Department of Internal Medicine, AP-HP, University Hospital Bichat, Paris, France;

13. Department of Pathology, University Hospital La Pitié-Salpêtrière, Paris, France; and

14. INSERM UMR-S1147, CNRS SNC5014, Paris Descartes University, Paris, France

Abstract

Key Points BRAF V600E mutations are detectable in hematopoietic stem and progenitors in adults with histiocytosis. Transplantation of CD34+ cells from histiocytosis patients can give rise to genetically and phenotypically accurate xenografts.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

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