A phase 2 trial of pomalidomide and dexamethasone rescue treatment in patients with AL amyloidosis-Reference-Cited by-同舟云学术

A phase 2 trial of pomalidomide and dexamethasone rescue treatment in patients with AL amyloidosis

Published:2017-04-13 Issue:15 Volume:129 Page:2120-2123
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Palladini Giovanni¹²^ORCID,Milani Paolo¹²,Foli Andrea¹²,Basset Marco¹²,Russo Francesca¹²,Perlini Stefano³⁴,Merlini Giampaolo¹²^ORCID

Affiliation:

1. Amyloidosis Research and Treatment Center, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy;

2. Department of Molecular Medicine, University of Pavia, Pavia, Italy;

3. Internal Medicine, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy; and

4. Department of Internal Medicine, University of Pavia, Pavia, Italy

Abstract

Key Points PDex can be a rescue regimen for patients with AL amyloidosis previously exposed to alkylators, proteasome inhibitors, and lenalidomide. Responses to PDex are frequent, rapid, and improve survival.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/129/15/2120/1399437/blood756528.pdf

Reference15 articles.

1. What is new in diagnosis and management of light chain amyloidosis?;Palladini;Blood,2016

2. Lenalidomide and dexamethasone in the treatment of AL amyloidosis: results of a phase 2 trial;Sanchorawala;Blood,2007

3. The activity of lenalidomide with or without dexamethasone in patients with primary systemic amyloidosis;Dispenzieri;Blood,2007

4. Salvage therapy with lenalidomide and dexamethasone in patients with advanced AL amyloidosis refractory to melphalan, bortezomib, and thalidomide;Palladini;Ann Hematol,2012

5. The combination of thalidomide and intermediate-dose dexamethasone is an effective but toxic treatment for patients with primary amyloidosis (AL);Palladini;Blood,2005

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