T regulatory cells and dendritic cells protect against transfusion-related acute lung injury via IL-10

Author:

Kapur Rick123,Kim Michael12,Aslam Rukhsana12,McVey Mark J.12345,Tabuchi Arata1,Luo Alice1456,Liu Jonathan12,Li Yuan127,Shanmugabhavananthan Shanjeevan12,Speck Edwin R.12,Zufferey Anne12,Yousef George8,Zhang Haibo1456,Rondina Matthew T.91011,Weyrich Andrew S.12,Porcelijn Leendert13,Kuebler Wolfgang M.11461516,Slutsky Arthur S.117,Semple John W.123185

Affiliation:

1. Keenan Research Centre for Biomedical Science and

2. The Toronto Platelet Immunobiology Group, St. Michael’s Hospital, Toronto, ON, Canada;

3. Canadian Blood Services, Toronto, ON, Canada;

4. Department of Anesthesia,

5. Department of Medicine, and

6. Department of Physiology, University of Toronto, Toronto, ON, Canada;

7. Department of Intensive Care, Qilu Hospital, Shandong University, Jinan, China;

8. Department of Laboratory Medicine, St. Michael’s Hospital, Toronto, ON, Canada;

9. Molecular Medicine Program and

10. Department of Internal Medicine, University of Utah, Salt Lake City, UT;

11. Department of Internal Medicine, George E. Wahlen Salt Lake City Veterans Affairs Medical Center, Salt Lake City, UT;

12. Program in Molecular Medicine, Department of Internal Medicine, University of Utah School of Medicine, Salt Lake City, UT;

13. Department of Thrombocyte and Leukocyte Serology, Sanquin Diagnostic Services, Amsterdam, The Netherlands;

14. Department of Surgery and

15. Institute of Physiology, Charité-Universitätsmedizin, Berlin, Germany;

16. German Heart Institute, Berlin, Germany;

17. Interdepartmental Division of Critical Care Medicine,

18. Department of Pharmacology,

Abstract

Key PointsCD4+CD25+FoxP3+ T regulatory cells and CD11c+ dendritic cells protect against antibody-mediated murine TRALI. Murine TRALI is associated with reduced IL-10 levels, and IL-10 administration prevents and rescues TRALI development.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

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