USP7 inhibition alters homologous recombination repair and targets CLL cells independently of ATM/p53 functional status-Reference-Cited by-同舟云学术

USP7 inhibition alters homologous recombination repair and targets CLL cells independently of ATM/p53 functional status

Published:2017-07-13 Issue:2 Volume:130 Page:156-166
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Agathanggelou Angelo¹,Smith Edward¹,Davies Nicholas J.¹,Kwok Marwan¹²,Zlatanou Anastasia¹,Oldreive Ceri E.¹,Mao Jingwen¹,Da Costa David¹,Yadollahi Sina¹,Perry Tracey¹,Kearns Pamela¹,Skowronska Anna¹,Yates Elliot¹,Parry Helen¹²,Hillmen Peter³,Reverdy Celine⁴,Delansorne Remi⁴,Paneesha Shankara⁵,Pratt Guy¹²,Moss Paul¹²,Taylor A. Malcolm R.¹,Stewart Grant S.¹,Stankovic Tatjana¹

Affiliation:

1. Institute of Cancer and Genomic Sciences, College of Medical and Dental Sciences, University of Birmingham, Birmingham, United Kingdom;

2. Centre for Clinical Haematology, Queen Elizabeth Hospital Birmingham, Birmingham, United Kingdom;

3. Section of Experimental Haematology, Leeds Institute of Cancer and Pathology, University of Leeds, Leeds, United Kingdom;

4. Hybrigenics Services, Paris, France; and

5. Heartlands Hospital, Birmingham, United Kingdom

Abstract

Key Points USP7 is overexpressed and regulates HRR in CLL cells. USP7 inhibition is selectively cytotoxic to CLL cells independently of ATM and p53 and synergizes with chemotherapy.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/130/2/156/1404337/blood758219.pdf

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