A dual role for the class III PI3K, Vps34, in platelet production and thrombus growth-Reference-Cited by-同舟云学术

A dual role for the class III PI3K, Vps34, in platelet production and thrombus growth

Published:2017-11-02 Issue:18 Volume:130 Page:2032-2042
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Valet Colin¹,Levade Marie¹²,Chicanne Gaëtan¹,Bilanges Benoit³,Cabou Cendrine¹⁴,Viaud Julien¹,Gratacap Marie-Pierre¹,Gaits-Iacovoni Frédérique¹,Vanhaesebroeck Bart³,Payrastre Bernard¹²,Severin Sonia¹

Affiliation:

1. Institut des Maladies Métaboliques et Cardiovasculaires, Inserm U1048, Université Toulouse III, Toulouse, France;

2. Laboratoire d’Hématologie, Centre Hospitalier Universitaire de Toulouse, Toulouse, France;

3. UCL Cancer Institute, University College London, London, United Kingdom; and

4. Faculté de Pharmacie, Université Toulouse III, Toulouse, France

Abstract

Key Points Vps34 controls intracellular trafficking, migration, and platelet production in MKs. Vps34 and its stimulation-dependent PI3P production regulate platelet secretion and thrombus growth.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/130/18/2032/1403467/blood781641.pdf

Reference46 articles.

1. Phosphoinositides in cell regulation and membrane dynamics;Di Paolo;Nature,2006

2. The emerging mechanisms of isoform-specific PI3K signalling;Vanhaesebroeck;Nat Rev Mol Cell Biol,2010

3. Characterization of VPS34, a gene required for vacuolar protein sorting and vacuole segregation in Saccharomyces cerevisiae;Herman;Mol Cell Biol,1990

4. Phosphatidylinositol 3-phosphate, a lipid that regulates membrane dynamics, protein sorting and cell signalling;Schink;BioEssays,2013

5. The intricate regulation and complex functions of the class III phosphoinositide 3-kinase Vps34;Backer;Biochem J,2016

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