Platelet microparticles infiltrating solid tumors transfer miRNAs that suppress tumor growth-Reference-Cited by-同舟云学术

Platelet microparticles infiltrating solid tumors transfer miRNAs that suppress tumor growth

Published:2017-08-03 Issue:5 Volume:130 Page:567-580
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Michael James V.¹²,Wurtzel Jeremy G. T.¹²,Mao Guang Fen²,Rao A. Koneti²³,Kolpakov Mikhail A.⁴⁵,Sabri Abdelkarim⁴⁵,Hoffman Nicholas E.⁶⁷,Rajan Sudarsan⁶⁷,Tomar Dhanendra⁶⁷,Madesh Muniswamy⁶⁷,Nieman Marvin T.⁸,Yu Johnny⁹¹⁰,Edelstein Leonard C.⁹¹⁰,Rowley Jesse W.¹¹¹²,Weyrich Andrew S.¹¹¹²¹³,Goldfinger Lawrence E.¹²¹⁴

Affiliation:

1. Department of Anatomy & Cell Biology,

2. The Sol Sherry Thrombosis Research Center,

3. Department of Medicine,

4. Department of Physiology,

5. Cardiovascular Research Center,

6. Department of Biochemistry, and

7. Center for Translational Medicine, Lewis Katz School of Medicine, Temple University, Philadelphia, PA;

8. Department of Pharmacology, Case Western Reserve University, Cleveland, OH;

9. Cardeza Foundation for Hematologic Research and

10. Department of Medicine, Sidney Kimmel Medical School, Thomas Jefferson University, Philadelphia, PA;

11. Department of Internal Medicine,

12. Program in Molecular Medicine, and

13. Division of Microbiology and Immunology, Department of Pathology, University of Utah School of Medicine, Salt Lake City, UT; and

14. Cancer Biology Program, Fox Chase Cancer Center, Philadelphia, PA

Abstract

Key Points Platelet MPs infiltrate solid tumors and transfer platelet-derived miRNAs to tumor cells within solid tumors in vivo. Transfer of platelet miRNAs to tumor cells results in downregulation of tumor cell genes and inhibition of solid tumor growth.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/130/5/567/1403991/blood751099.pdf

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