Non-Coding RNAs and Innate Immune Responses in Cancer
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Published:2024-09-11
Issue:9
Volume:12
Page:2072
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ISSN:2227-9059
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Container-title:Biomedicines
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language:en
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Short-container-title:Biomedicines
Author:
Díaz Carlos Romero1, Hernández-Huerta María Teresa2ORCID, Mayoral Laura Pérez-Campos3ORCID, Villegas Miriam Emily Avendaño1ORCID, Zenteno Edgar4ORCID, Cruz Margarito Martínez1, Mayoral Eduardo Pérez-Campos3, del Socorro Pina Canseco María3, Andrade Gabriel Mayoral3, Castellanos Manuel Ángeles4ORCID, Matías Salvador José Manuel5, Cruz Parada Eli1ORCID, Martínez Barras Alexis6, Cruz Fernández Jaydi Nora3, Scott-Algara Daniel7ORCID, Pérez-Campos Eduardo18ORCID
Affiliation:
1. Tecnológico Nacional de México/IT Oaxaca, Oaxaca 68030, Mexico 2. Consejo Nacional de Humanidades, Ciencias y Tecnologías (CONAHCyT), Facultad de Medicina y Cirugía, Universidad Autónoma “Benito Juárez” de Oaxaca (UABJO), Oaxaca 68020, Mexico 3. Centro de Investigación, Facultad de Medicina UNAM-UABJO, Universidad Autónoma “Benito Juárez” de Oaxaca (UABJO), Oaxaca 68020, Mexico 4. Facultad de Medicina, Universidad Nacional Autónoma de Mexico, Ciudad de México 04510, Mexico 5. Hospital General Dr. Aurelio Valdivieso, Oaxaca 68040, Mexico 6. Facultad de Ingeniería, Universidad Autónoma de Querétaro, Querétaro 76017, Mexico 7. Unité de Biologie Cellulaire des Lymphocytes and Direction of International Affairs, Institut Pasteur, 75015 Paris, France 8. Laboratorio de Patología Clínica “Dr. Eduardo Pérez Ortega”, Oaxaca 68000, Mexico
Abstract
Non-coding RNAs (ncRNAs) and the innate immune system are closely related, acting as defense mechanisms and regulating gene expression and innate immunity. Both are modulators in the initiation, development and progression of cancer. We aimed to review the major types of ncRNAs, including small interfering RNAs (siRNAs), microRNAs (miRNAs), piwi-interacting RNAs (piRNAs), and long non-coding RNAs (lncRNAs), with a focus on cancer, innate immunity, and inflammation. We found that ncRNAs are closely related to innate immunity, epigenetics, chronic inflammation, and cancer and share properties such as inducibility, specificity, memory, and transfer. These similarities and interrelationships suggest that ncRNAs and modulators of trained immunity, together with the control of chronic inflammation, can be combined to develop novel therapeutic approaches for personalized cancer treatment. In conclusion, the close relationship between ncRNAs, the innate immune system, and inflammation highlights their importance in cancer pathways and their potential as targets for novel therapeutic strategies.
Funder
French National Agency for Research on AIDS, Viral Hepatitis, and emerging and reemerging infectious diseases Juarez Autonomous University of Oaxaca
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