Incidence and prognostic value of TET2 alterations in de novo acute myeloid leukemia achieving complete remission

Author:

Nibourel Olivier1234,Kosmider Olivier5,Cheok Meyling234,Boissel Nicolas6,Renneville Aline1234,Philippe Nathalie1,Dombret Hervé6,Dreyfus François7,Quesnel Bruno2348,Geffroy Sandrine1,Quentin Samuel9,Roche-Lestienne Catherine1234,Cayuela Jean-Michel9,Roumier Christophe1234,Fenaux Pierre10,Vainchenker William11,Bernard Olivier A.12,Soulier Jean9,Fontenay Michaëla5,Preudhomme Claude1234

Affiliation:

1. Laboratoire d'hématologie, Centre Hospitalier Regional Universitaire de Lille, Lille;

2. Inserm, U837, Lille;

3. Universitaire Lille Nord de France, Lille;

4. Institut de Recherche sur le Cancer de Lille, Lille;

5. Inserm Unité 567, Centre National de la Recherche Scientifique Unite Mixte de Recherche 8104 and Institut Cochin; Laboratoire d'Hématologie, Hôpital Cochin (Assistance Publique–Hopitaux de Paris[AP-HP]), Université Paris V-René Descartes, Paris;

6. Service d'hématologie adulte, Hôpital Saint Louis (AP-HP), Université Paris VII, Paris;

7. Service d'hématologie clinique, Hôpital Cochin (AP-HP), Université Paris V-René Descartes, Paris;

8. Service des maladies du sang, Centre Hospitalier Universitaire de Lille, Lille;

9. Inserm U944, Institut Universitaire d'Hématologie, Laboratoire Central d'Hématologie, Hôpital Saint Louis (AP-HP), Université Paris VII, Paris;

10. Service hématologie, Hôpital Avicenne (AP-HP)–Université Paris XIII, Bobigny;

11. Inserm U790, Institut Gustave Roussy, Université Paris XI, Villejuif; and

12. Inserm Eo210, Hôpital Necker, Faculté de Médecine, Université Paris V, René Descartes, Paris, France

Abstract

Abstract Mutations of the ten eleven translocation 2 gene (TET2) have recently been reported in myelodysplastic syndrome and myeloproliferative neoplasms. We analyzed the incidence and prognostic value of TET2 point mutations and other genomic alterations by direct sequencing and single nucleotide polymorphism microarray analysis in 111 de novo acute myeloid leukemia, who had all achieved complete remission (CR). Mutations were observed in 19 (17%) of the 111 patients compared with 10 (27%) of 36 patients who had failed to achieve CR (P = .2). In the 111 patients who had achieved CR, TET2 alterations were only significantly associated with NPM1 mutations but not with other pretreatment characteristics. TET2 gene status was not significantly correlated with disease-free survival and overall survival, both in the entire cohort and in patients with normal karyotype.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

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