Early detection and evolution of preleukemic clones in therapy-related myeloid neoplasms following autologous SCT

Author:

Berger Gerbrig1,Kroeze Leonie I.2,Koorenhof-Scheele Theresia N.2,de Graaf Aniek O.2,Yoshida Kenichi3,Ueno Hiroo3,Shiraishi Yuichi4,Miyano Satoru4,van den Berg Eva5,Schepers Hein1,van der Reijden Bert A.2,Ogawa Seishi3,Vellenga Edo1,Jansen Joop H.2

Affiliation:

1. Department of Hematology, Cancer Research Center Groningen, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands;

2. Department of Laboratory Medicine, Laboratory of Hematology, Radboud University Medical Center, Nijmegen, The Netherlands;

3. Department of Pathology and Tumor Biology, Kyoto University, Kyoto, Japan;

4. Human Genome Center, Institute of Medical Science, the University of Tokyo, Tokyo, Japan; and

5. Department of Genetics, University Medical Center Groningen, University of Groningen, The Netherlands

Abstract

Key Points tMNs after ASCT originate from HSCs bearing (pre-)tMN mutations that are present years before disease onset. Post-ASCT treatment can influence selection and outgrowth of (pre)leukemic clones.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

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