Evolving risk of therapy-related acute myeloid leukemia following cancer chemotherapy among adults in the United States, 1975-2008

Author:

Morton Lindsay M.1,Dores Graça M.12,Tucker Margaret A.1,Kim Clara J.1,Onel Kenan3,Gilbert Ethel S.1,Fraumeni Joseph F.1,Curtis Rochelle E.1

Affiliation:

1. Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD;

2. Department of Veterans Affairs Medical Center, Oklahoma City, OK; and

3. Department of Pediatrics, University of Chicago, Chicago, IL

Abstract

Key Points Coincident with major changes in cancer treatments, the occurrence of tAML has changed significantly with time. The risks for tAML should be weighed against the benefits of chemotherapy.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Reference49 articles.

1. Howlader N Noone A Krapcho M SEER Cancer Statistics Review, 1975-2009, National Cancer Institute. Bethesda, MD, http://seer.cancer.gov/csr/1975_2009/; 2012

2. International workshop on the relationship of prior therapy to balanced chromosome aberrations in therapy-related myelodysplastic syndromes and acute leukemia: overview report.;Rowley;Genes Chromosomes Cancer,2002

3. Therapy-related myeloid leukemia.;Godley;Semin Oncol,2008

4. Therapy-related myeloid neoplasms.;Czader;Am J Clin Pathol,2009

5. Incidence and susceptibility to therapy-related myeloid neoplasms.;Leone;Chem Biol Interact,2010

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