Phosphatidylinositol transfer proteins regulate megakaryocyte TGF-β1 secretion and hematopoiesis in mice-Reference-Cited by-同舟云学术

Phosphatidylinositol transfer proteins regulate megakaryocyte TGF-β1 secretion and hematopoiesis in mice

Published:2018-09-06 Issue:10 Volume:132 Page:1027-1038
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Capitano Maegan¹,Zhao Liang²,Cooper Scott¹,Thorsheim Chelsea²,Suzuki Aae²,Huang Xinxin¹,Dent Alexander L.¹^ORCID,Marks Michael S.³⁴,Abrams Charles S.²,Broxmeyer Hal E.¹

Affiliation:

1. Department of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, IN;

2. Penn-CHOP Blood Center for Patient Care and Discovery and Hematology-Oncology Division, Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA;

3. Department of Pathology and Laboratory Medicine, Children’s Hospital of Philadelphia, Philadelphia, PA; and

4. Department of Physiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA

Abstract

Key Points PITPs facilitate TGF-β1 secretion in megakaryocytes regulating hematopoiesis. Pitpα −/− /β −/− megakaryocytes have a defect in α-granule morphology and function.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/132/10/1027/1406652/blood806257.pdf

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